Nnmultiple myeloma pathogenesis pdf

Cell of origin and genetic alterations in the pathogenesis. Request pdf pathogenesis of multiple myeloma multiple myeloma mm is monoclonal tumor of antibody secreting plasma cells pc in the bone marrow bm, that is often diagnosed by the presence. B is essential in mm pathogenesis and has been found to. Genes localized to the copy number change regions are often. Multiple myeloma is a clonal malignancy of terminally differentiated b lymphocytes characterized by the expansion of clonal plasma cells in the bone marrow resulting in. Multiple myeloma mm is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an.

Multiple myeloma is an incurable disease and, little is known about the genetic and molecular mechanism governing its pathogenesis 3. Pathogenesis beyond the cancer clones in multiple myeloma. First described in 1848, mm is characterized by a proliferation of malignant plasma cells and a subsequent overabundance of monoclonal paraprotein m protein. Lightning bolts represent genetic mutations common in. Although the pathogenetic mechanisms of disease have been clarified to a large extent, mm remains an incurable disease with low life expectancy. Mm is preceded by an ageprogressive premalignant condition termed. Failure of apoptosis, angiogenesis and bone marrow interaction with malignant cells.

Pathophysiology and diagnosis of multiple myeloma jatin shah, md, explains that there is no clear reason for why patients develop multiple myeloma, and so theres no clear risk factor. Multiple myeloma is a form of cancer that affects bone marrow, the spongy soft tissue that lies within the hollow centre of some bones. It is characterized by a multifocal proliferation of clonal, long lived. Multiple myeloma mm is a neoplasm of postgerminal center, terminally differentiated b cells. It is characterized by a multifocal proliferation of clonal, longlived. Multiple myeloma mm is a debilitating malignancy that is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance mgus to plasma cell leukemia. Multiple myeloma mm is a b cell malignancy resulting in osteolytic lesions and fractures.

Pathogenesis and treatments cliodhna browne tsmj issue 10 2009 30 abstract multiple myeloma is a clonal b cell malignancy involving terminally differentiated plasma cells. Immunoglobulin gene rearrangements and the pathogenesis of multiple myeloma. Multiple myeloma is a heamatologic malignancy caused by clonal expansion of malignant plasma cells, associated with bone disease and hypercalcaemia as its primary metabolic complication. Abstract multiple myeloma mm, an incurable hematologic malignancy. Molecular pathogenesis of multiple myeloma request pdf. A unifying event in the pathogenesis of multiple myeloma is the dysregulated expression of a cyclin d gene, either directly by juxtaposition to an immunoglobulin enhancer, as a result of ectopic expression of a maf family transcription factor, or indirectly by as yet unidentified mechanisms. Multiple myeloma mm is the second most common blood cancer. It is characterized by a multifocal proliferation of clonal, longlived plasma cells within the bone marrow bm and associated skeletal destruction, serum monoclonal gammopathy, immune suppression, and endorgan sequelae. Multiple myeloma is the second most common type of blood cancer after leukemia. Multiple myeloma mm is an agedependent monoclonal tumor of bm plasma cells pcs.

Leif bergsagel 2 1 genetics branch, center for cancer. The role of bone marrow microenvironment in mediating survival, proliferation, and resistance to therapy in myeloma is well established. Learn more about the symptoms, causes, diagnosis, risk factors, and treatment of multiple myeloma. Multiple myeloma mm is a plasma cell dyscrasia characterized by malignant proliferation of monoclonal plasma cells in the bone marrow. Molecular pathogenesis of multiple myeloma and its premalignant.